Postdoctoral Research Fellow - Macromolecular Crystallography Membrane Structural and Functional Biology University of Limerick, Ireland

Highlights:

1. The University of Limerick is inviting applications for the post of Postdoctoral Research Fellow in the Membrane Structural and Functional Biology Research Group.
2. The major theme within the Group is structure and function of membrane proteins by crystallographic means.
3. Systems under investigation include receptors, transducers, transporters, respiratory complexes, and quorum sensing-related and biofilm forming membrane proteins of Pseudomonas aeruginosa.
4. Purified protein and in meso-grown crystals of several targets are already in hand.
5. Required:
a. A Ph.D. in macromolecular X-ray crystallography
b. Experience and demonstrated success with macromolecular crystallization
c. Experience and demonstrated mastery of all of the aspects of X-ray
crystal structure determination
d. Experience and demonstrated mastery of the latest crystallographic
software
e. Recent experience and demonstrated mastery of on-site data collection at
a synchrotron X-ray source
f. Availability and willingness to travel to synchrotrons and collaborators worldwide
g. A commitment to quality and innovative research
6. Desirable:
a. Expertise using and maintaining a home X-ray generator, diffractometer
and cryo-system
b. Expertise maintaining latest crystallographic software
c. Expertise with low-resolution phasing and refinement
d. Expertise with molecular dynamics simulations, electrostatic pKa and redox
potential calculations, comparative modeling methods, and docking simulations
e. Expertise collecting data with mini- or micro-X-ray beams (< 20 um)
f. Expertise with small-angle X-ray scattering
g. Experience over-expressing, purifying and crystallizing proteins, membrane
proteins in particular
7. The candidate should be a highly motivated individual who enjoys working as
part of a collaborative, multidisciplinary team. Strong leadership,
communication and teaching skills are decided assets.
8. Maximum available starting salary 47,606 Euro
9. The closing date for receipt of applications is Wednesday, 15th July
2009.
10. Further information for applicants and application material are
available online from: http://www.ul.ie/hrvacancies/

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